FDA had no questions. UnSugar Sweet Protein is ready for your next launch.

Company news · Reviewed by the UnSugar R&D Team

UnSugar Sweet Protein. The best way to take sugar out.

The 30-second version

• FDA has responded to the GRAS Notice for UnSugar Sweet Protein, GRN 001338, with a “no questions” letter dated November 4, 2026.
• It covers use as a general-purpose sweetener in foods, excluding infant formula and products under USDA jurisdiction.
• UnSugar Sweet Protein is 1,000 times sweeter than sugar and replaces 60 to 90% of the sugar in suitable formulations.
• We make it in our own manufacturing facility, and commercial supply has started.
• The fastest next step: a sample box with a certificate of analysis in about 7 days.

The U.S. Food and Drug Administration (FDA) has responded to the GRAS Notice for UnSugar Sweet Protein, GRN 001338, with a “no questions” letter. In the letter, dated November 4, 2026, FDA states that it has no questions at this time about the conclusion that UnSugar Sweet Protein (brazzein) is Generally Recognized as Safe (GRAS) under its intended conditions of use as a general-purpose sweetener in foods at levels consistent with current good manufacturing practices, excluding infant formula and products under USDA jurisdiction.

Key facts

• Regulatory status: FDA GRAS notice closed with a “no questions” letter, GRN 001338, dated November 4, 2026.
• Timeline: notice submitted March 2, 2026; FDA letter November 4, 2026.
• Sweetness: 1,000 times sweeter than sugar, so it is used in milligrams.
• Sugar reduction: replaces 60 to 90% of the sugar in suitable formulations.
• Taste: clean, sugar-like sweetness with no bitter aftertaste; works alongside stevia and monk fruit.
• Process: holds its sweetness up to about 98 °C (208 °F).
• Formats: liquid and powder.
• Getting started: a sample box with a certificate of analysis in about 7 days, and a free review of each customer’s first trial.
• Supply: made in UnSugar’s own manufacturing facility; commercial supply has started; capacity growing about tenfold in the coming months.
• Purity: brazzein makes up more than 90% of the protein in every lot, confirmed by a certificate of analysis.

Made by UnSugar, start to finish

UnSugar owns and runs its own manufacturing. We control quality from strain to shipment and ship every lot with a certificate of analysis. Commercial supply has started, and we are growing capacity about tenfold in the coming months, so brands can plan launches knowing the supply will be there. Read more about manufacturing and supply.

What a “no questions” letter means

Under FDA’s GRAS Notification Program, a company submits the scientific basis for its conclusion that an ingredient is safe for its intended use, and FDA evaluates the notice. A “no questions” letter is the response FDA issues when it has no questions about that conclusion. FDA posts its response letters in its public GRAS Notice Inventory. Until the entry for GRN 001338 is updated, we share a copy of the letter on request.

FDA does not “approve” GRAS ingredients, so we never call UnSugar Sweet Protein “FDA approved”. What we have is FDA’s “no questions” letter, which is the outcome companies seek when they notify FDA.

Why it matters now

The letter arrives as FDA considers making GRAS notification mandatory. Under a proposed rule published on August 11, 2026, ingredients already covered by an FDA “no questions” letter for their intended use would be exempt from the new notification requirement. Comments on the proposal are due December 9, 2026.

For your team, that means the regulatory question that stalls many sweet protein projects is settled, and the work can start at the bench.

How to get started

Food and beverage teams can request a sample box, request specifications and regulatory documentation, and read the full FDA status on our regulatory and quality page.

• For brands: cut sugar, keep your fans, and buy direct from the maker. Talk to a specialist.
• For formulators: it doesn’t take over your recipe. It just makes it sweet. Request samples.
• For independent sales reps: carry the sweet protein your customers will ask about. Represent UnSugar.
• For distributors: supply direct from the maker, with full documents. Become a distributor.

UnSugar Sweet Protein is the first of several ingredients from our fermentation platform. More are on the way.

Ready when you are

A sample box with a certificate of analysis reaches US teams in about 7 days, and we review your first trial free of charge. One gram of powder can replace up to about 1 kg of sugar.

Request a sample boxRead the FDA status

Quick answers

What did FDA say? FDA responded to the GRAS Notice for UnSugar Sweet Protein, GRN 001338, with a “no questions” letter dated November 4, 2026.

Is UnSugar Sweet Protein FDA approved? FDA does not approve GRAS ingredients. It reviews GRAS notices. FDA reviewed ours (GRN 001338) and responded with a “no questions” letter on November 4, 2026, meaning it has no questions about the conclusion that UnSugar Sweet Protein is GRAS for its intended use.

Where can I see the letter? FDA posts its response letters in its public GRAS Notice Inventory under the notice number, GRN 001338. Until that entry is updated, we share a copy on request, and the full status is on our regulatory page.

What is UnSugar Sweet Protein? A sweet protein (brazzein) that is 1,000 times sweeter than sugar, available as a liquid and a powder.

How do I start? Request a sample box. It arrives with a certificate of analysis in about 7 days, and we review your first trial free of charge.

Media contact

UnSugar Media Team, sales@goUnSugar.com, +1 (651) 317-8261. See also our company facts.

Reduction figures are formulation targets, confirmed by bench testing in your own product. Performance and labeling depend on the finished formulation, use level and applicable regulations; confirm any on-pack wording with your regulatory team. We make no health, glycemic or calorie claims for UnSugar Sweet Protein.